POS1302 THE MUSCULOSKELETAL SYSTEM MANIFESTATIONS IN CHILDREN WITH FAMILIAL MEDITERRANEAN FEVER

Background: Familial Mediterranean fever (FMF) is a monogenic inherited periodic syndrome presenting with episodes of self-limiting and inflammation serosal membranes. The attacks emerge arthritis were defined as one the major diagnostic criteria besides involvement Non-specific musculoskeletal findings such myalgia, arthralgia, transient synovitis, more rare manifestations like protracted febrile myalgia can also be seen in FMF patients Objectives: We aim to reveal frequency genotype association children FMF. Methods: diagnosed between January 1, 2017 June 2019, followed for at least 6 months our pediatric rheumatology clinic included study. Musculoskeletal enrolled. grouped according “Mediterranean Fever” (MEFV) gene variants. compared groups Results: study group 634 (336 female 298 male, F/M: 1.13/1). clinical attack period follows: 99% had fever, 87.3% abdominal pain, 20.7% chest 11.3% vomiting, 10.7% erysipelas erythema, 9.3% headache. symptoms accompanied by 58.6% (n: 372) during period. most common manifestation was found arthralgia (32.6%, n: 206). Also, other musculosceletal follows attacks; 23.7% 150), 20.5% 130), exertional calf pain 6.5% 41), 1% 7) patients. It observed that significantly higher homozygous M694V variant exon-10 (p=0.017). it are periods carrying allele (p = 0.019). Conclusion: determined an symptom than half compound heterozygous MEFV mutations including risk factor manifestations. In unexplained recurrent symptoms, especially ethnicities high FMF, analysis help underlying cause. References: [1]Brik R, Shinawi M, Kasinetz L, Gershoni-Baruch R. familial genetically disease. Arthritis Rheum 2001;44:1416-9. [2]Jarjour RA, Dodaki patterns mutation. Mol Biol Rep 2011;38:2033-6. Disclosure Interests: None declared